Cytokines in gingivocrevicular fluid of rheumatoid arthritis patients: A review of the literature
Identifieur interne : 000913 ( Main/Exploration ); précédent : 000912; suivant : 000914Cytokines in gingivocrevicular fluid of rheumatoid arthritis patients: A review of the literature
Auteurs : Poerwati S. Rahajoe ; Menke J. Smit ; Nyoman Kertia ; Johanna Westra ; Arjan VissinkSource :
- Oral Diseases [ 1354-523X ] ; 2019.
Abstract
Rheumatoid arthritis (RA) and periodontitis share several pathological features including bone and soft tissue destruction and high levels of circulating inflammatory proteins. Studies related to cytokines in the periodontal inflammatory exudate (gingivocrevicular fluid, GCF) of RA patients might provide insight into the association between periodontitis and RA. The aim of our study was to review the literature on cytokines in GCF of RA patients including the effect of anti‐rheumatic treatment with biological disease‐modifying anti‐rheumatic drugs (DMARDs) and periodontal treatment on these cytokines.
MedLine/PubMed searches with different combinations of keywords “rheumatoid arthritis or RA” and “crevicular fluid or GCF” until June 2019 revealed 64 articles. Ten cross‐sectional observational studies and nine treatment studies fulfilled the inclusion criteria.
Rheumatoid arthritis patients have increased circulating and GCF levels of pro‐inflammatory cytokines and proteins, despite anti‐rheumatic treatment with biological DMARDs. Presence of periodontitis was accompanied by higher cytokine and protein levels. Treatment of periodontitis resulted in a decrease of these levels.
Analysis of GCF of RA patients reveals that the relationship between periodontitis and RA is bidirectional, probably caused by a non‐specific inflammatory burden. Data for a specific relationship are barely present in GCF.
Url:
DOI: 10.1111/odi.13145
PubMed: 31206910
PubMed Central: 6853197
Affiliations:
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Smit</name><affiliation><nlm:aff id="odi13145-aff-0002"></nlm:aff></affiliation></author><author><name sortKey="Kertia, Nyoman" sort="Kertia, Nyoman" uniqKey="Kertia N" first="Nyoman" last="Kertia">Nyoman Kertia</name><affiliation><nlm:aff id="odi13145-aff-0003"></nlm:aff></affiliation></author><author><name sortKey="Westra, Johanna" sort="Westra, Johanna" uniqKey="Westra J" first="Johanna" last="Westra">Johanna Westra</name><affiliation><nlm:aff id="odi13145-aff-0004"></nlm:aff></affiliation></author><author><name sortKey="Vissink, Arjan" sort="Vissink, Arjan" uniqKey="Vissink A" first="Arjan" last="Vissink">Arjan Vissink</name><affiliation><nlm:aff id="odi13145-aff-0005"></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">31206910</idno><idno type="pmc">6853197</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6853197</idno><idno type="RBID">PMC:6853197</idno><idno type="doi">10.1111/odi.13145</idno><date when="2019">2019</date><idno type="wicri:Area/Pmc/Corpus">000346</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000346</idno><idno type="wicri:Area/Pmc/Curation">000346</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000346</idno><idno type="wicri:Area/Pmc/Checkpoint">000852</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000852</idno><idno type="wicri:Area/Ncbi/Merge">000710</idno><idno type="wicri:Area/Ncbi/Curation">000710</idno><idno type="wicri:Area/Ncbi/Checkpoint">000710</idno><idno type="wicri:doubleKey">1354-523X:2019:Rahajoe P:cytokines:in:gingivocrevicular</idno><idno type="wicri:Area/Main/Merge">000913</idno><idno type="wicri:Area/Main/Curation">000913</idno><idno type="wicri:Area/Main/Exploration">000913</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Cytokines in gingivocrevicular fluid of rheumatoid arthritis patients: A review of the literature</title><author><name sortKey="Rahajoe, Poerwati S" sort="Rahajoe, Poerwati S" uniqKey="Rahajoe P" first="Poerwati S." last="Rahajoe">Poerwati S. Rahajoe</name><affiliation><nlm:aff id="odi13145-aff-0001"></nlm:aff></affiliation></author><author><name sortKey="Smit, Menke J" sort="Smit, Menke J" uniqKey="Smit M" first="Menke J." last="Smit">Menke J. Smit</name><affiliation><nlm:aff id="odi13145-aff-0002"></nlm:aff></affiliation></author><author><name sortKey="Kertia, Nyoman" sort="Kertia, Nyoman" uniqKey="Kertia N" first="Nyoman" last="Kertia">Nyoman Kertia</name><affiliation><nlm:aff id="odi13145-aff-0003"></nlm:aff></affiliation></author><author><name sortKey="Westra, Johanna" sort="Westra, Johanna" uniqKey="Westra J" first="Johanna" last="Westra">Johanna Westra</name><affiliation><nlm:aff id="odi13145-aff-0004"></nlm:aff></affiliation></author><author><name sortKey="Vissink, Arjan" sort="Vissink, Arjan" uniqKey="Vissink A" first="Arjan" last="Vissink">Arjan Vissink</name><affiliation><nlm:aff id="odi13145-aff-0005"></nlm:aff></affiliation></author></analytic><series><title level="j">Oral Diseases</title><idno type="ISSN">1354-523X</idno><idno type="eISSN">1601-0825</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Abstract</title><sec id="odi13145-sec-0001"><title>Objective</title><p>Rheumatoid arthritis (RA) and periodontitis share several pathological features including bone and soft tissue destruction and high levels of circulating inflammatory proteins. Studies related to cytokines in the periodontal inflammatory exudate (gingivocrevicular fluid, GCF) of RA patients might provide insight into the association between periodontitis and RA. The aim of our study was to review the literature on cytokines in GCF of RA patients including the effect of anti‐rheumatic treatment with biological disease‐modifying anti‐rheumatic drugs (DMARDs) and periodontal treatment on these cytokines.</p></sec><sec id="odi13145-sec-0002"><title>Materials and methods</title><p>MedLine/PubMed searches with different combinations of keywords “rheumatoid arthritis or RA” and “crevicular fluid or GCF” until June 2019 revealed 64 articles. Ten cross‐sectional observational studies and nine treatment studies fulfilled the inclusion criteria.</p></sec><sec id="odi13145-sec-0003"><title>Results</title><p>Rheumatoid arthritis patients have increased circulating and GCF levels of pro‐inflammatory cytokines and proteins, despite anti‐rheumatic treatment with biological DMARDs. Presence of periodontitis was accompanied by higher cytokine and protein levels. Treatment of periodontitis resulted in a decrease of these levels.</p></sec><sec id="odi13145-sec-0004"><title>Conclusion</title><p>Analysis of GCF of RA patients reveals that the relationship between periodontitis and RA is bidirectional, probably caused by a non‐specific inflammatory burden. 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